Longitudinal analysis of low-molecular weight fluorophores in type 1 diabetes mellitus.

نویسندگان

  • Andrzej S Januszewski
  • Merlin C Thomas
  • Connie S Karschimkus
  • Jasmine S Chung
  • Kevin G Rowley
  • Craig L Nelson
  • David N O'Neal
  • George Dragicevic
  • Colin A Harper
  • James D Best
  • Alicia J Jenkins
چکیده

OBJECTIVES Circulating low molecular weight (<10 kDa) fluorophores (LMW-F) measured by non-specific fluorescence spectroscopy may detect small advanced glycation end-products (AGEs) not recognized by other assays. This longitudinal study assessed correlates of LMW-F and predictive power of LMW-F levels for vascular health in Type 1 diabetes (T1DM) patients. METHODS Fasting patients with T1DM (n=37) were studied twice at intervals of 12-60 months (mean+/-SD, 33+/-15 months). LMW-F levels were also measured once in 112 healthy control subjects. RESULTS Relative to controls, LMW-F levels were higher in diabetic subjects at initial and final time points (mean+/-SD), 5.4+/-1.9 AU/ml and 4.5+/-1.8 AU/ml respectively vs. 3.8+/-2.1 AU/ml; p=0.0001 and p=0.06). Baseline LMW-F levels predicted subsequent hs-CRP and oxLDL/LDL values. LMW-F levels decreased significantly over time in diabetes (5.4+/-1.9 vs. 4.5+/-1.8 AU/ml; p=0.02). Rises in LMW-F levels in individual diabetic subjects correlated significantly with worsening renal function (BUN), glycemia (HbA1c) and with vascular dysfunction (systemic vascular resistance). CONCLUSIONS LMW-F levels predict levels of inflammation and oxidation in T1DM. Changes in LMW-F levels in T1DM reflect variations in glycemia and renal function. Biochemical characterization of LMW-F would facilitate understanding of the potential utility of LMW-F as a therapeutic target.

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عنوان ژورنال:
  • The journal of medical investigation : JMI

دوره 55 1-2  شماره 

صفحات  -

تاریخ انتشار 2008